Sulphur-Containing Metabolites of β-Bromostyrene Formed by the Marmoset, Rabbit and Rat

Abstract

1. The administration of β-bromostyrene to the rat results in a fall in the level of hepatic glutathione.

2. Marmosets, rabbits and rats dosed with β-bromostyrene excrete two mercapturic acids. One of these, N-acetyl-S-(2-hydroxy-2-phenyl-1-bromoethyl)-cysteine is readily converted into N-acetyl-S- (1-phenyl-2-bromo-2-ethenyl)-cysteine, the structure of which was established by mass spectrometry.

3. Mass spectrometric evidence suggests that the second mercapturic acid is N-acetyl-S-(1-hydroxy-2-phenylethyl)cysteine.

4. Mandelic acid was detected as a metabolite in all three species.