The Metabolites of Procaterol HC1 in Urine and Faeces of Dog and Man

Abstract

1. The metabolites of procaterol HC1 in dog urine and faeces and in human urine were qualitatively analysed by an improved g.l.c.-mass spectrometric method.

2. Trimethylsilylated derivatives of procaterol metabolites were identified by mass fragmentography as procaterol glucuronide, 5-(2-amino-1-hydroxybutyl)-8-hydroxycarbostyril (desisopropylprocaterol), 5-formyl-8-hydroxycarbostyril, 8-hydroxycarbostyril and unchanged procaterol.

3. The metabolic pattern of procaterol HC1 was species-independent in rats, dogs and man.