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Xenobiotica
the fate of foreign compounds in biological systems
Volume 8, 1978 - Issue 12
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Research Article

The Metabolism and Excretion of Curcumin (1,7-Bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) in the Rat

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Pages 761-768 | Received 05 Jun 1978, Published online: 22 Sep 2008
 

Abstract

1. Cureumin labelled with deuterium and tritium was prepared. Oral and intraperitoneal doses of [3H]curcumin led to the faecal excretion of most of the radioactivity.

2. Intravenous and intraperitoneal doses of [3H]curcumin were well excreted in the bile of cannulated rats.

3. The major biliary metabolites were glucuronides of tetrahydrocurcumin and hexahydrocurcumin. A minor biliary metabolite was dihydroferulic acid together with traces of ferulic acid. Metabolites were identified using chemical ionization mass spectrometry.

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