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Xenobiotica
the fate of foreign compounds in biological systems
Volume 8, 1978 - Issue 12
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Research Article

A Comment on the Formation of an N-Hydroxymethyl Intermediate in the Metabolism of N-Methylcarbazole

R. T. Coutts Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, T6G 2N8, Canada
,
G. R. Jones Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, T6G 2N8, Canada
,
A. Benderly Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, T6G 2N8, Canada
&
D. J. Temple Department of Pharmacy, The Queen's University of Belfast, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland
Pages 779-780 | Received 10 May 1978, Published online: 22 Sep 2008
 
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Abstract

Interpretation of the mass spectrum of the N-methylcarbazole used in a previous metabolism study suggests that the substrate was grossly contaminated with carbazole. The present study refutes that suggestion.

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