N-Formylation of an Aromatic Amine as a Metabolic Pathway

S. V. Gothoskar Laboratory of Carcinogen Metabolism, National Cancer Institute, Bethesda, Maryland, 20205, USA

T. Benjamin Laboratory of Carcinogen Metabolism, National Cancer Institute, Bethesda, Maryland, 20205, USA

P. P. Roller Laboratory of Carcinogen Metabolism, National Cancer Institute, Bethesda, Maryland, 20205, USA

E. K. Weisburger Laboratory of Carcinogen Metabolism, National Cancer Institute, Bethesda, Maryland, 20205, USA

Abstract

1. Feeding 2-aminoanthraquinone (2-AAQ) in the diet to Fischer rats led to nephro-toxicity in females, caused by deposits of crystalline material in the kidney tubules.

2. This material consisted of 2-AAQ, N-acetyl-2-AAQ and N-formyl-2-AAQ. N-Formyl-2-AAQ was also identified in the ether extract of urine of rats fed 2-AAQ.

3. This represents the first case of identification of the N-formyl derivative of a primary aromatic amine as a metabolite in vivo.

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N-Formylation of an Aromatic Amine as a Metabolic Pathway

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N-Formylation of an Aromatic Amine as a Metabolic Pathway

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