Avian Metabolism of Halogenated Biphenyls

Abstract

1. The metabolism of several halogenated biphenyls has been studied using poultry as a model system. The substrates 4-chlorobiphenyl and 4-bromobiphenyl each yielded two metabolites (4′-chloro-4-biphenylol, 4′-chloro-3,4-biphenyldiol; 4′-bromo-4-biphenylol, 4′-bromo-3,4-biphenyldiol), while 4,4′-dichlorobiphenyl yielded only one metabolite (4,4′-dichloro-3-biphenylol).

2. Metabolites were not found in eggs collected for 7 days following the administration of the substrate.