Liver microsomal oxidations in baboon (Papio papio)

Abstract

1. The activity of baboon (Papio papio) hepatic microsomes was evaluated using several model substrates.

2. As with other species studied in this laboratory, baboon microsomal enzyme activities were in the decreasing order: aldrin epoxidation > p-nitroanisole O-demethyl-ation > dihydroisodrin hydroxylation > benzo(a)pyrene oxidations.

3. Substrate, time, protein and cofactor requirements were examined.

4. Activities of stored frozen tissue and microsomal pellets remained similar up to seven days.

5. In the six animals studied (three male, three female), no differences in hepatic microsomal activity due to sex were apparent.