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Abstract
1. A major route of metabolism of the methylmercaptotriazine herbicide cyanatryn involves S-oxygenation.
2. The S-oxide reacts spontaneously with glutathione affording a conjugate, which is eliminated in the bile, and a mercapturic acid which is eliminated in the urine.
3. A small proportion of the administered dose was covalently bound to a component of the blood, probably haemoglobin. This was shown to be dependent on the formation of the S-oxide and on the species of animal studied.
4. No reactivity of the S-oxide towards DNA in vivo, or in vitro could be demonstrated.