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Xenobiotica
the fate of foreign compounds in biological systems
Volume 10, 1980 - Issue 5
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Research Article

The metabolism of 3-phenoxybenzoic acid and its glucoside conjugate in rats

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Pages 355-364 | Received 04 Sep 1979, Published online: 22 Sep 2008
 

Abstract

1. 3-Phenoxy[14C]benzoic acid administered orally to rats (0.76 to > 100mg/kg) is extensively metabolized and rapidly eliminated mostly via the urine.

2. The major metabolic pathway involves 4′-hydroxylation followed by conjugation of the resulting phenol with sulphate. Only minor amounts of amino acid and glucuronic acid conjugation were observed.

3. 3-Phenoxy[14C]benzoyl glucoside, derived from the metabolism of the acid by corn leaves, was also rapidly absorbed by rats and eliminated as a mixture of metabolites very similar to that derived from 3-phenoxybenzoic acid. It was concluded that the glucoside conjugate was rapidly hydrolysed to the free acid in vivo.

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