![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
1. The effects of phenylhydroxylamine, and o- and p-aminophenol were studied in the Japanese quail.
2. Symptoms normally observed in aniline-treated birds were seen in quail after phenylhydroxylamine dosage at > 10mg/kg. Aminophenols (up to 50mg/kg) did not give these symptoms.
3. Injection of phenylhydroxylamine (50mg/kg) resulted in formation of 70% ferrihaemoglobin after 5min, following which a rapid reduction of ferrihaemoglobin was observed.
4. Phenylhydroxylamine reached highest blood concn. of 0.2μmol/ml after 5min. Phenylhydroxylamine was reduced to aniline within 5 min.
5. The effects of aniline in vivo are most probably due to O2 shortage caused by ferrihaemoglobin formation.