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Xenobiotica
the fate of foreign compounds in biological systems
Volume 10, 1980 - Issue 7-8
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Research Article

Metabolism of clebopride in vitro Identification of N-oxidized products

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Pages 593-602 | Received 16 Nov 1979, Published online: 22 Sep 2008
 

Abstract

1. N-(1′-Benzyl-4′-piperidyl-N-oxide)-4-amino-5-chloro-2-methoxybenzamide,N-(4′-(N-hydroxylpiperidyl))-4-amino-5-chloro-2-methoxybenzamide and N-(4′-(Δ1′-piperidyl-N-oxide))-4-amino-5-chloro-2-methoxybenzamide were obtained from chloro- form extracts of incubation mixtures of clebopride or desbenzyl clebopride with 9000g supernatant of liver homogenates of male NZW rabbits.

2. These metabolites were identified using electron impact (low and high resolution) and field desorption mass spectrometry, and computer averaged time proton magnetic resonance spectroscopy.

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