Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 10, 1980 - Issue 7-8
6
Views
13
CrossRef citations to date
0
Altmetric
Research Article

Evidence for p-hydroxylation of N-ethyl-N-methylaniline

&
Pages 603-610 | Received 10 Feb 1980, Published online: 22 Sep 2008
 

Abstract

1. N,N-Dialkyl- and N-alkyl-4-aminophenols derived from N-ethyl-N-methylaniline have been isolated from incubation mixtures of rabbit hepatic microsomes fortified with an NADPH-generating system.

2. This is the first report of metabolic ring (4-C) hydroxylation in vitro of an N,N-dialkylaniline.

3. N-Ethyl-N-methyl-4-aminophenol was the major ring-hydroxylation product, whilst N-ethyl-4-aminophenol and N-methyl-4-aminophenol were formed in approx. equal amounts at about 15% of the tertiary compound.

4. An apparent Vmax of 1.8 nmol/mg protein per min and Km of 1.7 × 10−4M were determined for N-ethyl-N-methyl-4-aminophenol formation using an optimized incubation time of 10 min.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.