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Abstract
1. 1α,2α-Epoxyhexahydrocannabinol was identified as a metabolite of Δ1-tetrahydrocannabinol.
2. The two trans-1,2-dihydroxyhexahydrocannabinol isomers, 1α,2β-dihydroxy-hexahydrocannabinol and 1β,2α-dihydroxyhexahydrocannabinol (as their acetates) were tentatively identified as metabolites from incubation of 1α,2α-epoxyhexahydrocannabinol with rat hepatic microsomes in vitro.
3. The 1α,2α-epoxyhexahydrocannabinol acetate was found to be a good substrate for epoxide hydratase as compared to styrene oxide.
4. The synthesis of metabolites of 1α,2α-epoxyhexahydrocannabinol is described.