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Xenobiotica
the fate of foreign compounds in biological systems
Volume 10, 1980 - Issue 11
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Research Article

A study of the debrisoquine hydroxylation polymorphism in a Nigerian population

, , , , &
Pages 811-818 | Received 15 Mar 1980, Published online: 22 Sep 2008
 

Abstract

1. The metabolic oxidation of debrisoquine has been studied in a group of 123 Nigerian volunteers.

2. All subjects excreted unchanged drug together with five oxidation products, namely, 4-, 5-, 6-, 7- and 8-hydroxy-debrisoquine.

3. The 4-hydroxylation reaction exhibits polymorphism; ten subjects were defective in their ability to effect this reaction.

4. The incidence (q) of the allele governing impaired 4-hydroxylation (DL) among Nigerians was calculated as being 0.28 (95% confidence limit of 0.20–0.37).

5. An association was demonstrated between the ability to effect 4-hydroxylation and 6- and 7-hydroxylation of debrisoquine, suggesting that the alleles controlling alicyclic oxidation also influence aromatic hydroxylation.

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