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Xenobiotica
the fate of foreign compounds in biological systems
Volume 10, 1980 - Issue 12
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Research Article

Identification of the major biliary metabolite of (+)-catechin in the rat

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Pages 905-911 | Received 16 Jun 1980, Published online: 22 Sep 2008
 

Abstract

1. Following oral administration of [U-14C]-(+)-catechin to the rat, the major biliary metabolite was shown to be the glucuronide of 3′-O-methyl-(+) catechin by chromatography and mass spectrometry.

2. [methyl-14C]-O-Methyl-(+)-catechin was formed by incubation of (+)-catechin with S-adenosyl-L-[methyl-14C]methionine in vitro in both liver homogenates and in the presence of purified catechol-O-methyl transferase.

3. Alkaline micro-fusion techniques have been used to determine the position of the O-methyl substituent in the B-ring of the isolated O-methyl-(+)-catechin glucuronide.

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