Identification of new urinary metabolites in man of quinine using methane chemical ionization gas chromatography-mass spectrometry

C. Liddle School of Physiology and Pharmacology University of New South Wales, P.O. Box 1, Kensington, NSW, 2033, Australia

G. G. Graham School of Physiology and Pharmacology University of New South Wales, P.O. Box 1, Kensington, NSW, 2033, Australia

R. K. Christopher Biomedical Mass Spectrometry Unit, University of New South Wales, P.O. Box 1, Kensington, NSW, 2033, Australia

S. Bhuwapathanapun Biomedical Mass Spectrometry Unit, University of New South Wales, P.O. Box 1, Kensington, NSW, 2033, Australia

A. M. Duffield Biomedical Mass Spectrometry Unit, University of New South Wales, P.O. Box 1, Kensington, NSW, 2033, Australia

Abstract

1. Six new metabolites of quinine have been identified in urine of man by methane chemical ionization g.l.c.-mass spectrometry.

2. Metabolites identified were: unchanged quinine and dihydroquinine, 3-hydroxy-quinine, 3-hydroxydihydroquinine, 6′-hydroxycinchonidine, 6′-hydroxydihydrocincho-nidine, quinine-10,11-epoxide and quinine-10,11-dihydrodiol.

3. 10-Chloro-11-hydroxydihydroquinine was identified as an artifact of the isolation procedure.

4. Chloroquine and desethylchloroquine (artifacts) were identified in the urine, 17 days after completion of a 48 h treatment with chloroquine.

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Identification of new urinary metabolites in man of quinine using methane chemical ionization gas chromatography-mass spectrometry

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Identification of new urinary metabolites in man of quinine using methane chemical ionization gas chromatography-mass spectrometry

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