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Abstract
1. The metabolism of 3-methoxyamphetamine in vivo was examined in dog, monkey and man.
2. The metabolites identified in all three species were 3-O-methyl-α-methyldopamine, 1-(3-methoxy-4-hydroxyphenyl)propan-2-ol, 3-hydroxyamphetamine, 1-(3-hydroxy-phenyl)propan-2-one, 1-(3-hydroxyphenyl)propan-2-ol, 1-(3-methoxyphenyl)propan-2-ol and 1-(3-methoxyphenyl)propane-1,2-diol.
3. 1-Hydroxy-1-(3-hydroxyphenyl)propan-2-one was tentatively identified in the urine of all three species.
4. 4-O-Methyl-α-methyldopamine was also found in the urine of dog and monkey but not in human urine.