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Xenobiotica
the fate of foreign compounds in biological systems
Volume 11, 1981 - Issue 3
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Research Article

The hydroxylation and dealkylation of some naphthyl alkyl ethers by rat liver microsomes

W. H. Hunter Pharmacy Department, Chelsea College, University of London, London, SW3 6LX, UK
&
P. Wilson School of Natural Sciences, The Hatfield Polytechnic, P.O. Box 109, Hatfield, AL10 9AB, UK
Pages 179-188 | Received 20 May 1980, Accepted 28 Nov 1980, Published online: 22 Sep 2008
 
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Abstract

1. The dealkylation and side-chain hydroxylation of 1 -(4-acetylnaphthyl) ethers by rat liver microsomes is described. The proportions of compounds metabolized by both routes are determined and shown to vary according to the length of the alkyl side-chain.

2. Metabolites formed by side-chain hydroxylation are identified by g.l.c.-mass spectrometry and by comparison with authentic materials.

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