3-(2,6-Xylyl)-5-methylhydantoin—a metabolite or a metabonate of tocainide in rats?

Abstract

1. G.l.c.-mass spectrometric analysis of urine extracts from rats dosed with tocainide (I) revealed the presence of a cyclic compound identified as 3-(2,6-xylyl)-5-methylhydantoin (IV) derived from tocainide.

2. Evidence indicates that IV is derived from a conjugate of tocainide (tocainide carbonyl O-β-D-glucuronide) (III) in humans.

3. Results of the present study indicate that in addition to being formed from a conjugate, IV is generated directly from tocainide in vivo in rats. Possible mechanisms for the formation of IV in rats in vivo are discussed.