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Xenobiotica
the fate of foreign compounds in biological systems
Volume 11, 1981 - Issue 4
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Research Article

Effect of aflatoxin B1 on hepatic drug-metabolizing enzymes in female rats. Interaction with a contraceptive agent

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Pages 275-279 | Received 20 Jul 1980, Published online: 22 Sep 2008
 

Abstract

1. The effect of a contraceptive on aflatoxin B1 toxicity has been studied in female rats treated for 15 consecutive days with repeated doses of aflatoxin (0·40mg/kg/day), norethindrone (0·60mg/kg/day) and ethynylestradiol (0·012mg/kg/day).

2. Increases occurred in hepatic microsomal cytochrome P-450 content (31%), and in the activities of epoxide hydrase (77%), UDP-glucuronyltransferase (67%) and γ-glutamyltransferase (78%).

3. Aflatoxin alone caused a 22% increase in GSH S-epoxide transferase activity, whereas the contraceptive given alone or combined with aflatoxin increased the hepatic reduced glutathione.

4. The effect of aflatoxin plus contraceptive was not additive.

5. The effects caused by aflatoxin and the contraceptive were similar, and the contraceptive (depending on its progestogen/estrogen ratio), may modify aflatoxin toxicity by increasing the drug-metabolizing enzyme activities and the concentration of hepatic glutathione.

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