Identification and quantification of diethylcarbamazine and diethylcarbamazine N-oxide in rat urine

G. Edwards Department of Pharmacology and Therapeutics, The University of Liverpool., P.O. Box 147, Liverpool, L69 3BX, UK

S. A. Ward Department of Pharmacology and Therapeutics, The University of Liverpool., P.O. Box 147, Liverpool, L69 3BX, UK

A. M. Breckenridge Department of Pharmacology and Therapeutics, The University of Liverpool., P.O. Box 147, Liverpool, L69 3BX, UK

M. L'e Orme Department of Pharmacology and Therapeutics, The University of Liverpool., P.O. Box 147, Liverpool, L69 3BX, UK

Abstract

1. Diethylcarbamazine and its major metabolite, diethylcarbamazine N-oxide have been identified and quantified in the urine of rats dosed orally with [¹⁴C]diethylcarbamazine citrate.

2. The urinary excretion of diethylcarbamazine N-oxide as percentage of dose was not dose-dependent.

3. These observations are in agreement with previous studies. As the metabolism of diethylcarbamazine in the rat differs greatly from man, the rat is unsuitable as an animal model in studies of diethylcarbamazine disposition.

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Identification and quantification of diethylcarbamazine and diethylcarbamazine N-oxide in rat urine

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Identification and quantification of diethylcarbamazine and diethylcarbamazine N-oxide in rat urine

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