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Xenobiotica
the fate of foreign compounds in biological systems
Volume 11, 1981 - Issue 4
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Research Article

Identification and quantification of diethylcarbamazine and diethylcarbamazine N-oxide in rat urine

G. Edwards Department of Pharmacology and Therapeutics, The University of Liverpool., P.O. Box 147, Liverpool, L69 3BX, UK
,
S. A. Ward Department of Pharmacology and Therapeutics, The University of Liverpool., P.O. Box 147, Liverpool, L69 3BX, UK
,
A. M. Breckenridge Department of Pharmacology and Therapeutics, The University of Liverpool., P.O. Box 147, Liverpool, L69 3BX, UK
&
M. L'e Orme Department of Pharmacology and Therapeutics, The University of Liverpool., P.O. Box 147, Liverpool, L69 3BX, UK
Pages 281-284 | Received 01 Dec 1980, Published online: 22 Sep 2008
 
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Abstract

1. Diethylcarbamazine and its major metabolite, diethylcarbamazine N-oxide have been identified and quantified in the urine of rats dosed orally with [14C]diethylcarbamazine citrate.

2. The urinary excretion of diethylcarbamazine N-oxide as percentage of dose was not dose-dependent.

3. These observations are in agreement with previous studies. As the metabolism of diethylcarbamazine in the rat differs greatly from man, the rat is unsuitable as an animal model in studies of diethylcarbamazine disposition.

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