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Abstract
1. Sulphamethazine was administered orally to 165 Yoruba subjects (40 mg/kg body wt.). Free and acetylated sulphamethazine were determined in the 6h urines.
2. The population frequency histogram for percentage of urinary acetylated sulphamethazine was bimodal, although not completely resolved. Slow acetylators constituted 45% of the population studied.
3. This Yoruba population did not differ statistically (P>0.05) in this respect from the two major tribally distinct groups in Nigeria previously investigated.