A system for the continuous collection of ¹⁴CO₂ from patas monkeys: the metabolism of [¹⁴C]cloguanamile

Abstract

1. An apparatus is described that allows CO₂ expired by monkeys to be trapped and measured and urine and faeces to be' separated and collected.

2. When [¹⁴C]cloguanamile was administered to rats and to patas monkeys, a marked species difference was seen in the proportion of ¹⁴CO₂ expired.

3. Suppression of the gut flora by neomycin revealed that this difference was due to enterofloral metabolism.