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Xenobiotica
the fate of foreign compounds in biological systems
Volume 11, 1981 - Issue 6
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Research Article

The fate of oxalic acid in the Wistar rat

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Pages 385-390 | Received 04 Dec 1980, Published online: 22 Sep 2008
 

Abstract

1. An established procedure for determining oxalate in human urine has been modified for rat urine. The daily excretion of oxalate by the male Wistar rat is 570-650 μg.

2. Oxalate excretion in rat urine following i.p. administration of [14C]oxalic acid (1-70mg/kg) has been studied. The rate and degree of excretion are dose-dependent.

3. The excretion of urinary oxalate by the rat has been quantified after administration of two oxalate-producing xenobiotics, α-chlorohydrin and 1,2-dibromo-3-chloropropane.

4. Oxalate inhibits the metabolism of glucose and lactate by isolated rat kidney tubules in vitro.

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