Metabolism of the epoxy resin component 2,2-bis[4-(2,3-epoxypropoxy)phenyl]propane, the diglycidyl ether of bisphenol a (DGEBPA) in the mouse.; Part I. A comparison of the fate of a single dermal application and of a single oral dose of ¹⁴C-DGEBPA

Abstract

1. ¹⁴C-DGEBPA dermally applied to mice was only slowly eliminated in the faeces (20% dose) and urine (3%), as a mixture of metabolites, over three days. Most of the applied radioactivity (66% dose) was extracted from the application area and its covering foil.

2. When ¹⁴C-DGEBPA was given orally to mice it was rapidly excreted; 80% of the administered ¹⁴C was eliminated in the faeces and 11% in the urine 0-3 days after a single oral dose.

3. The urinary and faecal metabolite profiles derived from dermal application and oral dosing were essentially similar.