Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 11, 1981 - Issue 7
30
Views
54
CrossRef citations to date
0
Altmetric
Review Article

Biotransformation of the fungicides hexachlorobenzene and pentachloronitrobenzene

Pages 435-446 | Received 14 Oct 1980, Accepted 20 May 1981, Published online: 22 Sep 2008
 

Abstract

This overview of the metabolism of the fungicides hexachlorobenzene (HCB) and pentachloronitrobenzene (PCNB) indicates similarities in their pathways of biotransformation. Several metabolites of HCB and PCNB, such as chlorinated benzenes, the mercapturic acid, thiophenols, thioanisoles and phenols are identical. Both fungicides initially react with glutathione, with elimination of chlorine or of the nitro group respectively. The conjugate, S-(pentachlorophenyl)glutathione, is further metabolized by cleavage of the glutamate and glycine residues and acetylation of the amino group of the cysteinyl moiety, to give the mercapturic acid N-acetyl-S-(pentachlorophenyl)cysteine, a major metabolite of HCB and PCNB in rats and rabbits respectively, which is further metabolized to simpler sulphur-containing products.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.