The metabolism and disposition of 3,5-dibromosalicylanilide in male and female rats

Abstract

1. The metabolism of the pesticide, 3,5-dibromosalicylanilide, has been studied, following oral administration to rats.

2. This compound is more toxic than other brominated salicylanilides, some fatalities being recorded at an oral dose of 100mg/kg.

3. 3,5-Dibromosalicylanilide is well absorbed, and excreted in urine and bile as sulphate and glucuronide conjugates of the parent compound and of several phenolic metabolites. Radioactivity was present in tissues (blood, kidney, liver, fat) six days after dosing with 3,5-dibromosalicyl[¹⁴C]anilide.

4. Sex-differences occur, both in excretion route and in the proportions of urinary metabolites.