Abstract
1. The metabolism of 1,3-dibromopropane has been investigated in the rat. Two conjugated metabolites have been isolated from the urine and identified as S-(3-hydroxypropyl)cysteine and N-acetyl-S-(3-hydroxypropyl)cysteine.
2. An oxidation product, identified as β-bromolactic acid, has been isolated as a urinary metabolite.
3. 1,3-Dibromopropane is not excreted unchanged in expired air or in the urine. Approx. 15% of the dose (100 mg/kg) is excreted as metabolic products over 50 h and 3±5%, as CO2 within 6 h, indicating that oxidation is the main route of detoxication.