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Abstract
1. 8α,9α-Epoxyhexahydrocannabinol (8α,9α-EHHC) was formed from δ8-tetrahydro-cannabinol (δ8-THC) by mouse liver microsomal preparation in the presence of an Nadph-generating system.
2. The epoxide was identified by t.l.c., g.l.c. and g.l.c.-mass spectrometry and, together with 11-hydroxy-δ8-THC (11-OH-δ8-THC), was determined by g.l.c.
3. When δ8-THC was incubated with mouse liver microsomal preparation, 8α,9α-EHHC and 11-OH-δ8-THC was formed to the extents of 14% and 23%, respectively, of the added δ8-THC.