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Xenobiotica
the fate of foreign compounds in biological systems
Volume 12, 1982 - Issue 10
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Research Article

The effect of configuration of the sulphate moiety on the metabolism of potassium octan-2-sulphate in the rat

, , , , &
Pages 611-616 | Received 17 May 1982, Published online: 22 Sep 2008
 

Abstract

1. A comparison was made of the metabolism of potassium D-(+)-octan 2-[35S]sulphate and potassium L-(-)-octan-2-[35S]sulphate in the rat.

2. Following administration of either enantiomer orally or i.v. the major proportion of the radioactivity was excreted in the urine within 24h. When either enantiomer was administered i.v. to rats with bile-duct and ureter cannulae, the majority of the radioactivity was eliminated in the urine within six hours with only small amounts in bile.

3. Both enantiomers were extensively degraded in vivo. The metabolic products were identical with those previously reported (Maggs et al 1982).

4. The major difference in the metabolite patterns was with respect to the relative amounts of hexanoate-5-sulphate: male and female urines contained approx. twice as much of this metabolite when the D-(+)-isomer was administered. In addition, isomer and sex-linked differences were observed with respect to the amounts of octanoate-7-sulphate.

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