Metabolism of paracetamol by the isolated perfused kidney of the homozygous Gunn rat

K. R. Emslie Departments of Pathology and Chemistry, University of Melbourne, Parkville, Victoria, 3052, Australia

I. C. Calder Departments of Pathology and Chemistry, University of Melbourne, Parkville, Victoria, 3052, Australia

S. J. Hart Departments of Pathology and Chemistry, University of Melbourne, Parkville, Victoria, 3052, Australia

J. D. Tange Departments of Pathology and Chemistry, University of Melbourne, Parkville, Victoria, 3052, Australia

Abstract

1. Isolated kidneys from homozygous Gunn rats were perfused with paracetamol in concentrations lower and higher than K_m for paracetamol oxidation in the albino rat kidney.

2. Glucuronylation of paracetamol was not detected at either concentration.

3. An increase in oxidative metabolism at the higher concentration, similar to that seen with the Sprague-Dawley rat kidney, did not occur with kidneys from homozygous Gunn rats.

4. This finding does not support the hypothesis that the enhanced nephrotoxicity of paracetamol observed in the homozygous Gunn rat in vivo is due to increased intrarenal formation of reactive metabolites.

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Metabolism of paracetamol by the isolated perfused kidney of the homozygous Gunn rat

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Metabolism of paracetamol by the isolated perfused kidney of the homozygous Gunn rat

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