A comparison of the metabolism and elimination of benzanilide and salicylanilide in the rat

S. C. Mitchell Department of Biochemistry, University of Birmingham, P.O. Box 363, Birmingham B15 2TT, UK

H. M. Norbury Department of Biochemistry, University of Birmingham, P.O. Box 363, Birmingham B15 2TT, UK

R. H. Waring Department of Biochemistry, University of Birmingham, P.O. Box 363, Birmingham B15 2TT, UK

P. M. Gadsden Department of Biochemistry, University of Birmingham, P.O. Box 363, Birmingham B15 2TT, UK

P. B. Wood Department of Biochemistry, University of Birmingham, P.O. Box 363, Birmingham B15 2TT, UK

Abstract

1. The metabolism and elimination of benzanilide and salicylanilide in rats were compared.

2. For both compounds, >70% dose was excreted in urine with 20% in faeces, in 3 days.

3. With [¹⁴C]benzanilide and [¹⁴C]salicylanilide, 40% and 35% respectively of the ¹⁴C was excreted in the bile in 24h.

4. Benzanilide was metabolized to 4'-hydroxybenzanilide (24%), 2-hydroxybenz-anilide (salicylanilide, 19%) and 2'-hydroxybenzanilide (13%), with small amounts of 4-hydroxybenzanilide.

5. Salicylanilide was excreted unchanged (56%) with small amounts of the 5-hydroxy and 4'-hydroxy-derivatives.

6. All metabolites were present as glucuronide conjugates; the free aglycones were not found.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

A comparison of the metabolism and elimination of benzanilide and salicylanilide in the rat

Information for

Open access

Opportunities

Help and information

A comparison of the metabolism and elimination of benzanilide and salicylanilide in the rat

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature