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Xenobiotica
the fate of foreign compounds in biological systems
Volume 12, 1982 - Issue 2
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Research Article

Hepatic microsomal metabolism of 1,3-butadiene

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Pages 137-144 | Received 14 Jul 1981, Published online: 22 Sep 2008
 

Abstract

1. In rat liver microsomes, 1,3-butadiene was metabolized to butadiene monoxide, which was subsequently transformed into 3-butene-1,2-diol by microsomal epoxide hydrolase.

2. In the metabolism of butadiene oxide in microsomes, four metabolites were detected, namely two steroisomers of DL-diepoxybutane, and two stereoisomers of 3,4-epoxy-1,2-butanediol. No meso-diepoxybutane was detected.

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