Metabolism of α-hexachlorocyclohexane. Free metabolites in urine and organs of rats

R. M. Macholz Central Institute of Nutrition, Center of Molecular Biology and Medicine, Academy of Sciences of the GDR, DDR-1505 Potsdam-Rehbrücke, A.-Scheunert-Allee 114–116, German Democratic Republic

R. Knoll Central Institute of Nutrition, Center of Molecular Biology and Medicine, Academy of Sciences of the GDR, DDR-1505 Potsdam-Rehbrücke, A.-Scheunert-Allee 114–116, German Democratic Republic

H.-J. Lewerenz Central Institute of Nutrition, Center of Molecular Biology and Medicine, Academy of Sciences of the GDR, DDR-1505 Potsdam-Rehbrücke, A.-Scheunert-Allee 114–116, German Democratic Republic

M. Petrzika Central Institute of Nutrition, Center of Molecular Biology and Medicine, Academy of Sciences of the GDR, DDR-1505 Potsdam-Rehbrücke, A.-Scheunert-Allee 114–116, German Democratic Republic

R. Engst Central Institute of Nutrition, Center of Molecular Biology and Medicine, Academy of Sciences of the GDR, DDR-1505 Potsdam-Rehbrücke, A.-Scheunert-Allee 114–116, German Democratic Republic

Abstract

1. The α-isomer of 1,2,3,4,5,6-hexachlorocyclohexane (HCH) is converted in rats to 1,2,4-trichlorobenzene, 2,3,4-trichlorophenol, 2,4,6-trichlorophenol, other trichlorophenols, and 2,3,4,6-tetrachlorophenol, which were excreted in urine.

2. α-HCH is also converted to 3,4, 6/5-pentachlorocyclohexene which is detectable in kidneys, but not in urine.

3. The results of this study are discussed with references to earlier work and to γ-HCH metabolism.

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Metabolism of α-hexachlorocyclohexane. Free metabolites in urine and organs of rats

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Metabolism of α-hexachlorocyclohexane. Free metabolites in urine and organs of rats

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