Metabolism of adiphenine. II. Identification of major excretion metabolites in rats

J. Michelot INSERM U71, B. P. 184, 63005 Clermont-Ferrand, Cedex; Laboratoire de Biophysique, Faculté de Médecine, 28 Place Henri Dunant, 63001 Clermont-Ferrand 3INSERM U197, Faculté de Médecine Alexis Carrel, 69008, Lyon, France

J. C. Madelmont INSERM U71, B. P. 184, 63005 Clermont-Ferrand, Cedex; Laboratoire de Biophysique, Faculté de Médecine, 28 Place Henri Dunant, 63001 Clermont-Ferrand 3INSERM U197, Faculté de Médecine Alexis Carrel, 69008, Lyon, France

B. Rousset INSERM U71, B. P. 184, 63005 Clermont-Ferrand, Cedex; Laboratoire de Biophysique, Faculté de Médecine, 28 Place Henri Dunant, 63001 Clermont-Ferrand 3INSERM U197, Faculté de Médecine Alexis Carrel, 69008, Lyon, France

P. Labarre INSERM U71, B. P. 184, 63005 Clermont-Ferrand, Cedex; Laboratoire de Biophysique, Faculté de Médecine, 28 Place Henri Dunant, 63001 Clermont-Ferrand 3INSERM U197, Faculté de Médecine Alexis Carrel, 69008, Lyon, France

R. Mornex INSERM U71, B. P. 184, 63005 Clermont-Ferrand, Cedex; Laboratoire de Biophysique, Faculté de Médecine, 28 Place Henri Dunant, 63001 Clermont-Ferrand 3INSERM U197, Faculté de Médecine Alexis Carrel, 69008, Lyon, France

G. Meyniel INSERM U71, B. P. 184, 63005 Clermont-Ferrand, Cedex; Laboratoire de Biophysique, Faculté de Médecine, 28 Place Henri Dunant, 63001 Clermont-Ferrand 3INSERM U197, Faculté de Médecine Alexis Carrel, 69008, Lyon, France

Abstract

1. Major metabolites isolated from rat urine after administration of a single dose of [¹⁴C]adiphenine or [³H]adiphenine were identified by chromatography and n.m.r. spectrometry, and by comparison with authentic reference compounds chemically synthesized.

2. Adiphenine was extensively metabolized by hydrolysis of the ester bond into diethylaminoethanol, diphenylacetic acid, diphenylacetic acid glucuronide and, in small quantities, the corresponding glycine and glutamine conjugates.

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Metabolism of adiphenine. II. Identification of major excretion metabolites in rats

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Metabolism of adiphenine. II. Identification of major excretion metabolites in rats

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