Effect of perfluorodecalin on the microsomal mono-oxygenase system in perfused rat livers

Abstract

1. An emulsion of perfluorodecalin was used as a substitute for erythrocytes in a synthetic medium in the perfusion of isolated rat livers.

2. The efficiency of this oxygen carrier in maintaining liver viability and function was compared with an erythrocyte-containing medium.

3. Activities of the microsomal mono-oxygenase system, secretion of bile and concn. of transaminases, potassium, glucose, urea, pO₂ and pCO₂ in the medium, and ATP and glycogen in the tissue, did not differ in the two experimental conditions.