Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 13, 1983 - Issue 10
10
Views
13
CrossRef citations to date
0
Altmetric
Research Article

Metabolism of the mercapturic acid of 2,4′,5-trichlorobiphenyl in rats and mice

, , , &
Pages 597-605 | Received 29 Mar 1983, Published online: 22 Sep 2008
 

Abstract

1. 2,4′,5-Trichloro[14C]biphenyl mercapturic acids (triCB-MA) were metabolized in part to methylsulphide, methylsulphoxide and methylsulphone metabolites after i.p., i.v. (hepatic portal vein) and p.o. administration to rats.

2 Methylthio-triCB and triCB-MA were present in faeces and 3- and 4-methylsulphonyl-triCB (triCB-SO2CH3) were present in carcasses of all rats. Only triCB-SO2CH3 was present in lung tissue.

3. As shown by autoradiography, radioactivity accumulated in the tracheo-bronchial mucosa of mice given either intracaecal or tail-vein injections of triCB-MA.

4. Radioactivity extracted from the lungs of mice was shown to be present as triCB-SO2CH3.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.