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Xenobiotica
the fate of foreign compounds in biological systems
Volume 13, 1983 - Issue 12
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Research Article

Effect of pretreatment with hydroxylated xenobiotics on the activities of rat liver UDP-glucuronosyl-transferases

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Pages 755-761 | Received 15 Apr 1983, Published online: 22 Sep 2008
 

Abstract

1. Six hydroxylated substrates were examined as potential inducers of UDP-glucuronosyltransferases towards their conjugation and the conjugation of other ‘model’ aglycones with glucuronic acid. Time-dependence (4,14 and 28 days) and dose-dependence of treatments (from 25 mg/kg to 1 g/kg) were examined for some of these compounds.

2. Monoterpenoid alcohols (borneol and terpineol) did not enhance the glucuronidation of the ten substrates tested. p-Hydroxybiphenyl gives typical ‘substrate-induction’ towards its own conjugation.

3. Eugenol, a previously described inducer of UDP-glucuronosyltransferase activities in mouse, and 4-methylumbelliferone, give a general enhancement of all activities tested, especially those of the ‘3-methylcholanthrene-inducible’ group of aglycones. p-Nitrophenol at low dose (2.5 mg/kg) gives a limited ‘polycyclic aromatic hydrocarbon’-like increase.

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