Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 13, 1983 - Issue 5
18
Views
6
CrossRef citations to date
0
Altmetric
Original Article

Metabolic studies in the rat with 2,4,6-tri-t-butylphenol: a haemorrhagic antioxidant structurally related to butylated hydroxytoluene

&
Pages 319-326 | Received 24 Dec 1982, Published online: 30 Sep 2009
 

Abstract

1. Single oral doses of the haemorrhagic antioxidant 2,4,6-tri-t-butylphenol (260 mg/kg) were well absorbed in the rat. Peak blood levels of this compound were reached in 15-60 min. The blood elimination half-lives were 18.2 min for the α-phase and 11.8 h for the slower β-phase.

2. Max. tissue concns. of this compound were reached 2-3 h in the liver, 2-6 h in kidneys, 1.5-2.5 h in spleen and > 24h in epididymal adipose tissues.

3. This compound and its metabolites were not excreted in the urine; a metabolite but not the parent compound was detected in the faeces.

4. The faecal metabolite had a mol. wt. of 261, and was considered to be 2,4,6-tri-t-butylphenoxy radical.

5. 2,4,6-Tri-t-butylphenoxy radical was also detected in the bile of rats after oral administration of the parent phenol.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.