Induction of cytosolic glutathione transferase and microsomal epoxide hydrolase activities in extrahepatic organs of the rat by phenobarbital, 3-methylcholanthrene and trans-stilbene oxide

J. W. Depierre Department of Biochemistry, Arrhenius Laboratory, University of Stockholm, S-106 91, Stockholm, Sweden

J. Seidegård Department of Biochemistry, Arrhenius Laboratory, University of Stockholm, S-106 91, Stockholm, Sweden

R. Morgenstern Department of Biochemistry, Arrhenius Laboratory, University of Stockholm, S-106 91, Stockholm, Sweden

L. Balk Department of Biochemistry, Arrhenius Laboratory, University of Stockholm, S-106 91, Stockholm, Sweden

J. Meijer Department of Biochemistry, Arrhenius Laboratory, University of Stockholm, S-106 91, Stockholm, Sweden

A. Åström Department of Biochemistry, Arrhenius Laboratory, University of Stockholm, S-106 91, Stockholm, Sweden

I. Norélius Department of Biochemistry, Arrhenius Laboratory, University of Stockholm, S-106 91, Stockholm, Sweden

L. Ernster Department of Biochemistry, Arrhenius Laboratory, University of Stockholm, S-106 91, Stockholm, Sweden

show all

Abstract

1. The effects of treating male Sprague-Dawley rats with phenobarbital, 3-methylcholanthrene or trans-stilbene oxide on cytosolic glutathione transferase and microsomal epoxide hydrolase activities in the liver, intestine, kidney, lung, testis, adrenal, spleen, heart and brain have been investigated.

2. Studies on the time-courses of induction in liver demonstrate that these are complete after five days' treatment at the doses used.

3. Phenobarbital induces both cytosolic glutathione transferase and microsomal epoxide hydrolase activities significantly only in liver and intestine.

4. 3-Methylcholanthrene induces these activities in liver only.

5. Trans-Stilbene oxide induces both of these activities in liver and kidney, and cytosolic glutathione transferase activity in adrenal as well.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Induction of cytosolic glutathione transferase and microsomal epoxide hydrolase activities in extrahepatic organs of the rat by phenobarbital, 3-methylcholanthrene and trans-stilbene oxide

Information for

Open access

Opportunities

Help and information

Induction of cytosolic glutathione transferase and microsomal epoxide hydrolase activities in extrahepatic organs of the rat by phenobarbital, 3-methylcholanthrene and trans-stilbene oxide

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature