Xenobiotica

the fate of foreign compounds in biological systems

Volume 14, 1984 - Issue 7

Views

CrossRef citations to date

Altmetric

Original Article

The metabolism in animals and man of oxmetidine—A new histamine H₂-receptor antagonist

P. J. Cox Department of Drug Metabolism and Pharmacokinetics and Department of Physical Organic Chemistry, Smith Kline & French Research Ltd, The Frythe, Welwyn, Hertfordshire, AL6 9AR, UK

W. M. H. Heijbroek Department of Drug Metabolism and Pharmacokinetics and Department of Physical Organic Chemistry, Smith Kline & French Research Ltd, The Frythe, Welwyn, Hertfordshire, AL6 9AR, UK

D. C. Taylor Department of Drug Metabolism and Pharmacokinetics and Department of Physical Organic Chemistry, Smith Kline & French Research Ltd, The Frythe, Welwyn, Hertfordshire, AL6 9AR, UK

P. J. Wood Department of Drug Metabolism and Pharmacokinetics and Department of Physical Organic Chemistry, Smith Kline & French Research Ltd, The Frythe, Welwyn, Hertfordshire, AL6 9AR, UK

P. R. Cresswell Department of Drug Metabolism and Pharmacokinetics and Department of Physical Organic Chemistry, Smith Kline & French Research Ltd, The Frythe, Welwyn, Hertfordshire, AL6 9AR, UK

E. S. Pepper Department of Drug Metabolism and Pharmacokinetics and Department of Physical Organic Chemistry, Smith Kline & French Research Ltd, The Frythe, Welwyn, Hertfordshire, AL6 9AR, UK

P. J. Moore Department of Drug Metabolism and Pharmacokinetics and Department of Physical Organic Chemistry, Smith Kline & French Research Ltd, The Frythe, Welwyn, Hertfordshire, AL6 9AR, UK

R. C. Mitchell Department of Drug Metabolism and Pharmacokinetics and Department of Physical Organic Chemistry, Smith Kline & French Research Ltd, The Frythe, Welwyn, Hertfordshire, AL6 9AR, UK

T. J. A. Blake Department of Drug Metabolism and Pharmacokinetics and Department of Physical Organic Chemistry, Smith Kline & French Research Ltd, The Frythe, Welwyn, Hertfordshire, AL6 9AR, UK

J. S. Dawborne Department of Drug Metabolism and Pharmacokinetics and Department of Physical Organic Chemistry, Smith Kline & French Research Ltd, The Frythe, Welwyn, Hertfordshire, AL6 9AR, UK

R. Metcalf Department of Drug Metabolism and Pharmacokinetics and Department of Physical Organic Chemistry, Smith Kline & French Research Ltd, The Frythe, Welwyn, Hertfordshire, AL6 9AR, UK

P. Johnson Department of Drug Metabolism and Pharmacokinetics and Department of Physical Organic Chemistry, Smith Kline & French Research Ltd, The Frythe, Welwyn, Hertfordshire, AL6 9AR, UK

show all

Abstract

1. The absorption, distribution, metabolism and excretion of [¹⁴C]oxmetidine in rat, dog and man has been studied following both i.v. and oral administration.

2. Excretion is rapid and essentially complete in all three species. The biliary route is predominant.

3. Distribution of radioactivity is widespread although none is seen in the brain.

4. Metabolite patterns in urine from rat, dog and man have been compared by thin-layer chromatography.

5. Metabolite patterns in urine and bile from rat and dog have been compared by high-pressure liquid chromatography.

6. Six major metabolites have been isolated and identified including two O-glucuronides and one N-glucuronide.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

The metabolism in animals and man of oxmetidine—A new histamine H₂-receptor antagonist

Information for

Open access

Opportunities

Help and information

The metabolism in animals and man of oxmetidine—A new histamine H2-receptor antagonist

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature

The metabolism in animals and man of oxmetidine—A new histamine H₂-receptor antagonist