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Xenobiotica
the fate of foreign compounds in biological systems
Volume 14, 1984 - Issue 9
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Original Article

Biotransformation of derivatives of the fungicides pentachloronitrobenzene and hexachlorobenzene in mammals

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Pages 693-704 | Received 12 May 1983, Accepted 03 Mar 1984, Published online: 30 Sep 2009
 

Abstract

1. Biotransformation of N-acetyl-S-(2, 3, 5, 6-tetrachlorophenyl)cysteme and N-acetyl-S-(pentachlorophenyl)cysteine-S-oxide, of the metabolites of both PCNB and HCB, namely N-acetyl-S-(pentachlorophenyl)cysteine, pentachlorothiophenol, penta-chlorothioanisole, 4-methylthio-tetrachlorothiophenol and tetrachloro-1,4-bis(methyl-thio)benzene, and of the PCNB metabolites, S, S'-(tetrachloro-p-phenyleni')dicysteine, and the isomeric tetrachlorothiophenols, has been studied in rabbits, rats and mice, as well as in vitro.

2. Biotransformation products such as thiophenols, thioanisoles, chlorinated benzenes, phenols and anisoles have been identified by g.l.c.

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