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Xenobiotica
the fate of foreign compounds in biological systems
Volume 14, 1984 - Issue 9
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Original Article

Mechanisms of the reductive denitration of pentachloronitrobenzene (PCNB) and the reductive dechlorination of hexachlorobenzene (HCB)

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Pages 705-710 | Received 12 May 1983, Accepted 01 Mar 1984, Published online: 30 Sep 2009
 

Abstract

1. The reductive denitration of PCNB and the reductive dechlorination of HCB are complex, and begin with reaction of both fungicides with glutathione, with elimination of the nitro group and/or of chlorine, respectively.

2. The glutathione conjugates are further metabolized by cleavage of the glycine and glutamate residues to give cysteine conjugates or N-acetylcysteine conjugates by acetylation in mammals.

3. The cysteine derivatives are further metabolized by cleavage of the C-S bond to ptoduce thiophenols, which after reductive desulphuration form pentachlorobenzene, or minor chlorinated benzenes, respectively.

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