Abstract
1. Carpipramine administered orally is excreted via the urine and faeces in rat, rabbit, dog and man. Many metabolites are formed, including several conjugates in the urine.
2. A total of 20–25 metabolites was detected by t.l.c. and h.p.l.c., 16 of which were isolated and identified.
3. Three metabolic pathways were observed: (i) hydroxylation of the iminodibenzyl ring to a phenol or alcohol without modification of the side-chain, (ii) hydroxylation of the terminal piperidine of the 2-piperidinol side-chain, and (iii) cyclization and dehydrogenation of the same 2-piperidinol group.