Carpipramine metabolism in the rat, rabbit and dog and in man after oral administration

Abstract

1. Carpipramine administered orally is excreted via the urine and faeces in rat, rabbit, dog and man. Many metabolites are formed, including several conjugates in the urine.

2. A total of 20–25 metabolites was detected by t.l.c. and h.p.l.c., 16 of which were isolated and identified.

3. Three metabolic pathways were observed: (i) hydroxylation of the iminodibenzyl ring to a phenol or alcohol without modification of the side-chain, (ii) hydroxylation of the terminal piperidine of the 2-piperidinol side-chain, and (iii) cyclization and dehydrogenation of the same 2-piperidinol group.