Lack of congruence of S-carboxymethyl-L-cysteine sulphoxidation and debrisoquine 4-hydroxylation in a Caucasian population

Abstract

1. One-hundred-and-twenty volunteers and three families were investigated for possible association between the sulphoxidation of S-carboxymethyl-L-cysteine and the debrisoquine hydroxylation polymorphism.

2. The observed individual variations in these two metabolic reactions were shown not to be concordant (r_s = 0.068) and any heritable factors controlling the major aspects of these phenomena do not co-segregate.