![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
1. The urinary and faecal excretion, tissue distribution and metabolism of 3H-chloramphenicol (CP) were measured in rainbow trout, Salmo gairdneri R., after a single 50 mg/kg intragastric dose.
2. The major route of excretion of 3H was faecal (64·3% of the dose), with approx. 16% in the urine in five days.
3. Radioactivity was widely distributed in trout tissues and organs, the highest concen, being in the bile and intestine.
4. At 48 h after dosing, the radioactivity remaining in the liver, the muscle and the perigastric adipose tissue was as CP-derived compounds bound to tissues.
5. In addition to unchanged CP (4·3% dose after 96 h), the other metabolites excreted in the urine were CP base (5·2%), CP alcohol (4·0%) and CP glucuronide (1·8%).