Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 15, 1985 - Issue 2
23
Views
4
CrossRef citations to date
0
Altmetric
Research Article

Metabolism of phenylbutazone in rats

, &
Pages 123-128 | Received 23 Feb 1984, Published online: 22 Sep 2008
 

Abstract

1. The metabolism of phenylbutazone has been investigated in female rats dosed with the drug by gavage.

2. The major route of excretion is via the urine; 50% of the dose being excreted in the first 24 h. A small percentage of the dose is excreted in the faeces.

3. Following administration of 14C-phenylbutazone, five labelled, unconjugated hydroxy compounds were identified in the urine by t.l.c. and autoradiography; both hydrolysable and non-hydrolysable conjugates were found. Aqueous extracts of faeces contained O conjugates of oxyphenbutazone and 4-hydroxy-oxyphenbutazone (which may be a decomposition product).

4. Urine metabolites soluble in organic solvents were quantified by inverse isotope dilution assay and spectrophotometric analysis. The major metabolite is the γ-hydroxy derivative of phenylbutazone present both as the lactone and as the straight-chain compound, while oxyphenbutazone and pγ-dihydroxyphenylbutazone are minor metabolites.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.