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Xenobiotica
the fate of foreign compounds in biological systems
Volume 15, 1985 - Issue 7
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Research Article

Bucolome N-glucuronide: Purification and identification of a major metabolite of bucolome in rat bile

K. Mohri Department of Biopharmacy, Meiji College of Pharmacy, 1-35-23, Nozawa Setagaya-ku, Tokyo, 154, Japan
,
T. Uesugi Department of Biopharmacy, Meiji College of Pharmacy, 1-35-23, Nozawa Setagaya-ku, Tokyo, 154, Japan
&
K. Kamisaka The 3rd Department of Internal Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima Bunkyo-ku, Tokyo, 113, Japan
Pages 615-621 | Received 25 Jul 1984, Published online: 22 Sep 2008
 
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Abstract

1. A biliary metabolite of bucolome in rat was isolated and purified by column chromatography.

2. The metabolite has been identified as bucolome N3-glucuronide by chemical and spectroscopic data.

3. This study is the first to show an N-glucuronide to be the major metabolite of barbiturates in rat bile.

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