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Abstract
1. Electron-microscopic examinations of rat embryonic yolk sacs treated in vitro with 1˙5 × 10−5 M cyproheptadine showed proliferation of the lysosomal structures; other organelles remained unaffected, and also overall yolk-sac growth and vascularization were comparable to non-treated samples.
2. Radioactive measurements with 125I-labelled albumin showed that yolk sacs and embryos of the cyproheptadine-treated group incorporated less radioactivity than the controls.
3. Embryos inside the yolk sacs, treated either for 24 or 48 h, were severely retarded in growth and differentiation (∼ 50% of the controls).
4. It is suggested that the specific action of cyproheptadine on yolk-sac lysosomal structures, combined with reduced macromolecular transport, is the cause of inhibited embryonic development.