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Abstract
1. The metabolites of camazepam in rat plasma were characterized by t.l.c., mass spectroscopy and n.m.r. spectroscopy as the mono- or di-desmethylated metabolites and the mono- or di-hydroxymethylated metabolites.
2. The postulated metabolic pathways of camazepam involved step wise series of desmethylations.
3. The mono- and di-hydroxymethylated metabolites were found to be intermediates in desmethylation. Temazepam and oxazepam, metabolites of camazepam, were formed from the mono- or di-hydroxymethylated metabolites.